12:30 - FREE LUNCH - Sponsored by Kurt J. Lesker Company
1:00PM: Introduction and Welcome
1:10PM: Biomedical coatings using inverted cylindrical magnetron sputtering (Tentative title), by TBD, IsoFlux
1:45PM: DNA Sequencing Using Nanopores in Thin Film Arrays,
- Mark Akeson, University of California Santa Cruz
I will discuss development and implementation of the 100-gram MinION DNA sequencer which is based on protein nanopores embedded in synthetic, 50 Angstrom thin films. Approximately 500 nanopores are individually addressable using amplifiers in an application specific integrated circuit (ASIC). Long, 40,0000+ base pair individual genomic DNA strands can be read with this pocket sized device.
2:20PM: Coffee Break (Sponsored by UC Components)
2:30PM: Novel Use Of Reactive Multilayer Foil For Mars Planetary Exploration,
- Jacques Matteau, Indium Corporation
Previously we have presented a joining method whereby materials of widely differing CTE were successfully bonded with no deformation at room temperature using reactive multilayer foils as the local heat source. This is unique in as far as creating a metallic bond with any other technique results in significant deformation upon cooling back to room temperature.
In this presentation we will be looking into the deposition technique, testing and purpose of creating reactive multilayer films on three dimensional surfaces using conventional PVD deposition equipment. This is a preparation step for coating parts to create sterilized surfaces for a sample return experiment that would be flown to Mars, and the coatings may also have applications to Biomedical technologies for rapid sterilization needs.
3:05PM: Overcoming Fundamental Limitations of In Vitro Diagnostics Nanophotonic BioNEMS and Optofluidic Metasurfaces,
- Ali Yanik, University of California Santa Cruz
Nanophotonics is opening a myriad of unprecedented opportunities for biomedical applications by localizing light beyond the diffraction limit and dramatically boosting the light-matter interactions at nanoscale dimensions. In this talk, I will introduce a number of transformative technologies based on nanoscale control of light and fluidics on a chip. I will show how to overcome some of the fundamental limitations of the state of art techniques used in vitro diagnostics of infectious diseases and cancer.
About the Speaker: Ahmet Ali Yanik is an Assist. Professor of Electrical Engineering at University of California, Santa Cruz (UCSC). His current research focuses on isolation and single cell analysis of Circulating Tumor Cells (CTCs) from human blood using optofluidic-nanoplasmonic platforms. His research interests include nanoplasmonic and metamaterial devices for ultrasensitive infrared spectroscopy of biomolecules/chemicals as well as high-throughput, cost effective, BioNEMS technologies for life sciences, point-of-care diagnostics and global health. His expertise is in high-end nanolithography and bio-patterning as well as theory and engineering of nanophotonic devices. Before joining to UCSC, he was a senior research associate at BioMEMS Resource Center at Harvard Medical School and Surgery Department in Massachusetts General Hospital.
3:40PM: Atmospheric Pressure Plasma Based Fabrication of Low Cost Paper Biosensors,
- Ramprasad Gandhiraman, NASA Ames Research Center (USRA)
Paper based disposable biosensors are a recent development in medical diagnostics that has enabled low cost diagnosis of diseases in resource limited countries. Two important characteristics of paper sensors viz., i) lower weight and ii) ease of fabrication compared to the plastic and glass based biosensors are extremely attractive for long duration space missions. Paper sensors are ideal for micro-gravity environment as the flow of liquid is based on capillary action. Controlled integration of features that enhance the analytical performance of a sensor chip is a challenging task in the fabrication of paper sensors. Activation of the sensor surface and incorporation of signal transduction and/or signal amplification elements in a reliable and controllable manner is a key issue. Aerosol-assisted atmospheric plasma based process has been developed for fabrication of paper sensors. Functionalization of cellulose papers is carried out using the atmospheric plasma process for immobilization of biomolecules and for reduction of non-specific binding. Deposition of nanostructured materials for signal transduction/amplification is also carried out. A thorough characterization of the plasma fabricated paper sensors is carried out using synchrotron x ray source. A detailed analysis of the Near Edge X ray Absorption Fine Structure (NEXAFS) and its sensitivity to the local electronic structure of the carbon and nitrogen functionalities is presented. The ability to create hydrophilic and hydrophobic regions, site selective surface functionalization and incorporation of nanostructured materials opens up a range of capabilities and applications of paper based biosensors in micro-gravity environment.