TF Users Group - Announcements
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Topic: Bio-Nano, Bio-MEMS and Nano-MEMS Technology
Meeting Date: June 16, 2010
Time: 2:00 - 5:00pm
Agenda:
2:00 - 2:10 Welcome/Introduction
2:10 - 2:50 DNA Sequencing Technology,
- Xing Su, Intel
Abstract: DNA is the genetic material for living organisms and it has been known for a long time that some diseases are inherited. Studying the molecular basis of genetic diseases was not possible only until the discovery of DNA structure in 1953. Thanks to the inventions of PCR, DNA microarray and DNA sequencing technologies, the causes of many genetic diseases have been revealed at the molecular level. However, to evaluate systematically a patient's risk in a medical treatment, the individual’s genome must be sequenced. The goal of sequencing a human genome for under $1k has been the driving force for the rapid development of DNA sequencing technologies in recent years. In this presentation, the current progress of DNA analysis technologies is reviewed.
Bio: Dr. Xing Su received his Ph.D. in biology from University of California, Santa Barbara and completed his post-doctoral training in molecular biology from Harvard University. He was an instructor at Harvard Medical School for five years working on molecular neurosciences. He was with Affymetrix for about five years developing lab-on-a-chip technology. He joined Intel in 2001 to start nanotechnology and biosensor technology for bio applications. Currently, he is the lead scientist in the Integrated Biosystems Research at Intel. His major achievements include developing a gene-chip based large scale genotyping method that was the tool used to identify genome loci for several major human diseases (type II diabetes, etc), a miniaturized and fully integrated biochip platform, and a novel nano-material called COIN (composite organic inorganic nano-clusters). His current research interest is to develop molecular analysis technologies for biomedical applications using novel biochemistry and electronic sensor technology. He holds 31 issued patents with many patents pending. He is author and co-author of some 30 scientific papers.
2:50 - 3:30 A protein scaffold for nanotechnology and structured enzyme complexes for biofuels
- Chad Paavola, NASA
Abstract: The thermoacidiphilic archaeon Sulfolobus shibatae produces heat-inducible chaperonins comprised of ~60 kDa protein subunits assembled into 18-mer double rings. These double rings can, in turn, assemble into higher order structures such as two-dimensional crystals or bundled filaments. We have exploited this hierarchical self-assembly to create templates for hexagonal arrays of nanoparticles spaced on approximately 18 nm centers. We have shown that these templates can order metallic, semiconductor or magnetic particles. We have also turned this structural scaffold to the purpose of understanding the interactions among enzymes in the bacterial cellulosome, with the goal of producing new systems for deconstruction of plant cell wall biomass. This work has resulted in an enzyme complex that exhibits enhancement of enzymatic activity characteristic of previous work on cellulosomal enzymes.
Bio: Dr. Paavola received a B.S. in biochemistry from the University of Minnesota and a Ph. D. from the University of California at Berkeley, in molecular and cell biology. He went on to a post-doctoral fellowship at Duke University were he became involved in research on protein design and the application of a family of proteins as biosensors. He joined NASA Ames Research Center in 2001 to work in the area of protein-templated nanotechnology and to continue his research in the area of protein-based chemosensors.
Dr. Paavola's research interests revolve around the use of protein structures and protein - protein interactions to solve engineering problems. He directs projects in the use of protein complexes as templates for nanostructured materials, structured enzyme systems for bioenergy and protein-based sensors for biomarkers in extraterrestrial environments.
3:30 - 4:10 “Nanowires for microelectronics: realistic perspectives for on-wafer Si –compatible growth and applications”
- F. Iacopi, IMEC/The University of Tokyo
Abstract: The introduction of vertical nanostructures into microelectronics can bring the benefits of a larger flexibility in both device architecture and the combination of different semiconductor materials. For example, the electrical field in a vertical channel can be better controlled by an all-around gate. Also, for sufficiently small diameters, the hetero-junction between two mismatched materials can theoretically sustain significantly higher misfit strains without generating dislocations in a nanowire as compared to the conventional planar configuration.
In this talk we discuss how some fundamental issues linked to the Si –compatible wafer –scale fabrication of electronic devices based on nanowires can be solved. In particularly, a new approach for the choice of the VLS catalyst and the 300mm wafer –scale fabrication of aligned 1D nano- heterojunctions will be presented.
Bio: Francesca Iacopi received her MSc. in Physics in '96 from the University “La Sapienza”, Rome, Italy and her Ph.D. degree in E.E. in 2004, from the Katholieke Universiteit Leuven, Belgium. After graduation she worked on position-sensitive radiation detectors for the Italian National Institute for Nuclear Physics (INFN) and the European Centre for Nuclear Research (CERN), Switzerland. Since '99 she has joined IMEC (Leuven, Belgium) to conduct R&D projects on materials for microelectronics, namely ultra-low-k dielectrics and semiconductor nanowires. Since oct'09 she is appointed as Project Associated Professor at the University of Tokyo to explore new applications of cryogenic and super-critical fluid plasmas for materials processing. She is recipient of the Gold Award for graduate students from the Materials Research Society (Boston, Dec.2003), and author/co-author of over 100 peer-reviewed publications.
4:10 - 5:00 Break - Networking - Close of meeting
